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KMID : 1123920020160061270
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1270 ~ p.1276
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Cytotoxic and Antimicrobial Activities of Bioactive Monoterpenophenols
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Oh In-Kio
Lee Hyun-Ok
Ahn Jong-Woong
Kim Hyung-Min
Shin Ji-Hee
Lim Jin-A
Chun Hyun-Ja
Baek Seung-Hwa
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Abstract
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Compounds 1 - 12 were tested for their growth inhibitory effects against tumor cell lines using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays and antimicrobial activity. The cytotoxic activity of methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate (1) exhibit more active than that of 5-fluorouracil (11) on human oral epithelioid carcinoma (KB, ATCC No. OCL 17) cell lines. But this compound (1) on human skin melanoma (SK-MEL-3, HBT 69) cell lines shows less active than that of adriamycin (12). However, compound 9 showed the antimicrobial activity against S. epidermidis (MIC, 15.625 ㎍/㎖), S. aureus, C. albicans (MIC, 31.25 ㎍/㎖), S. mutans, S. typhimurium, P. putida (MIC. 125 ㎍/㎖) and P. aeruginosa (MIC, 500 ㎍/㎖).
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KEYWORD
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Growth inhibitory effects, MTT, SRB, KB, SK-MEL-3
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